Marshall Klaus Perinatal Research Awards
Klaus Awardees' Research Projects
The American Academy of Pediatrics (AAP), the Section on Perinatal Pediatrics, and Johnson & Johnson Pediatric Institute initiated the Marshall Klaus Perinatal Research Awards with the goal of enhancing and supporting development of research skills among physicians training in Neonatal-Perinatal Medicine. These awards provide partial support intended to assist fellows in initiating or completing research projects. Grants of $5,000/year are available.
Klaus Awards 2011
Lisa C Bain, MD - University of California San Francisco
“Factors Associated with Inadequate Screening for Retinopathy of Prematurity in California”
A first year Neonatology fellow at UCSF, Lisa also received her MD from UCSF, and traveled to Boston for her residency training at the Massachusets General Hospital for Children.
In this study, the California Perinatal Quality Care Collaborative database will be used to assess the variability in ROP screening rates across hospitals and to identify patient and hospital level factors associated with inadequate ROP screening. These results will form the basis for a future survey of NICU leadership, in which they will test the relationship between the systems-level factors and ROP screening rates. Interventions that imiprove screening rates can then be adopted as standard operating procedure to impact screening rates among neonates at risk for ROP.
Sabrina K Malik, MD - New York Medical College
“Effects of Preterm Birth on Neurogenesis”
My project examines how preterm birth affects neurogenesis. We are studying how preterm birth suppresses neurogenesis and pro-inflammatory cytokines mediate this effect. Our approach is to assess nurogenesis and pro-inflammatory cytokines in autopsy materials from premature infants and to evaluate the effect of pro-inflammatory cytokines on neurogenesis in a slice culture model from prematurely delivered rabbit pups.
A third year fellow at Maria Fareri Childrens Hospital, Sabrina completed her pediatric training at the University of Medicine and Dentistry in New Jersey. Looking forward to a career in neuroscience, her long term goals are to develop mechanism based treatment strategies to prevent brain injury in premature infants.
Mariya Spasova, MD , MD - Women and Infants Hospital
“Anti-Inflammatory Inverventions to Attenuate Ischemic Brain Damage in Fetal Sheep”
The overall goal of this proposal is to develop a novel effective therapeutic intervention to prevent and/or attenuate ischemia-related brain damage in the immature fetal brain using a naturally derived immunomodulator, Inter-Alpha Inhibitor Proteins (IAIPs). We hypothesize that systemic administration of IAIPs or their cleavage products reduce the production of pro-inflammatory cytokines and prevent/or attenuate the development of ischemia-reperfusion injury in the premature brain.
A second year fellow in neonatal-perinatal medicine at Women and Infants Hospital and the Warren Alpert Medical School of Brown University, Mariya received her medical degree from the Medical University, Sofia, Bulgaria, and PhD from the University of Rostock, Germany.