Marshall Klaus Perinatal Research Awards
Klaus Awardees Research Projects
The American Academy of Pediatrics (AAP), the Section on Perinatal Pediatrics, and Johnson & Johnson Pediatric Institute initiated the Marshall Klaus Perinatal Research Awards with the goal of enhancing and supporting development of research skills among physicians training in Neonatal-Perinatal Medicine. These awards provide partial support intended to assist fellows in initiating or completing research projects. Grants of $5,000/year are available.
Klaus Awards 2014
Sundeepta Kumar Basu, MD
Mentor: Bhagavatula Moorthy, MD
Molecular regulation of human cytochrome P4501A1 gene by hyperoxia in human lung cells: implications for bronchopulmonary dysplasia
Andrew Dylag , MD
Mentor: Richard Martin, MD
Long term airway hyperreactivity following neonatal chronic intermittent hypoxia with hyperoxia
Vikramaditya Dumpa, MD
Mentor: Vasanth Kumar
Rachel Heilman, MD
Mentor: Kathryn Farrow, MD
The role of PDE5 in the right ventricle in mice with hyperoxia-induced pulmonary hypertension
Thomas Hooven, MD
Mentor: Adam Ratner, MD
Tarek Mohamed , MD
Mentor: Bruce Uhal, PhD
Dr. Mohamed is fortunate to work with Dr. Bruce Uhal, whose lab has shown that during lung injury, the vasoactive peptide angiotensin II, independent of the "endocrine" renin-angiotensin system, induces collagen deposition and fibrosis, which eventually leads to abnormal restructuring of the lung architecture.
Dr. Mohamed's initial working hypothesis was that angiotensin converting enzyme (ACE-2) might be up- regulated in fetal lung fibroblasts exposed to hypoxia (simulating the physiologic fetal hypoxemia), which could in turn protect fetal lungs from undergoing fibrotic changes in response to hypoxemia. This may be germane in adult lung disease, as well, since "protective" ACE-2 levels may decline with age, thus explaining why the elderly are more at risk for lung fibrosis. Using the fetal lung fibroblast IMR-90 cell line, Dr. Mohamed's work will assay ACE-2 levels, enzymatic activity, and biochemical markers of fibrogenesis.
Eric Peeples , MD
Mentors: Sandra Juul, MD
Fast Doppler assessment of cerebral perfusion in preterm infants